GSK256066 (2,2,2-trifluoroacetic acid) rbidopa with Ki of 0

SKU: 85668535579

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GSK256066 (2,2,2-trifluoroacetic acid) rbidopa with Ki of 0GSK256066 is a potent and selective PDE4 inhibitor that can be given by inhalation, minimising the potential for side effects. GSK256066 demonstrated a protective effect on the EAR and LAR. GSK256066 is a slow and tight binding inhibitor of PDE4B (apparent IC(50) 3. 2 pM; steady state IC(50) <0. 5 pM), which is more potent than any previously documented compound, for example, roflumilast (IC(50) 390 pM), tofimilast (IC(50) 1. 6 nM), and cilomilast

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