![VH 298 20046 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N2CCN(CCCOC3=CC4=C(NC5=CC(Cl)=C(F)C=C5)N=CN=C4C=C3OC)CC2)C(C)(C)C)=CC=1](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M8047_1620717566.gif?v=1629192438)
VH 298 20046 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N2CCN(CCCOC3=CC4=C(NC5=CC(Cl)=C(F)C=C5)N=CN=C4C=C3OC)CC2)C(C)(C)C)=CC=1
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VH 298 20046 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N2CCN(CCCOC3=CC4=C(NC5=CC(Cl)=C(F)C=C5)N=CN=C4C=C3OC)CC2)C(C)(C)C)=CC=1VH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85
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