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Epalrestat - CAS# 82159-09-9 752 InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H

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Epalrestat - CAS# 82159-09-9 752 InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9HEpalrestat is an aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. In vivo, Epalrestat treatment significantly ameliorated the bleomycin mediated histological fibrosis alterations and blocked collagen deposition concomitantly with reversing bleomycin induced expression up regulation of TGF 1, AR, SMA and collagen I (both mRNA and protein). Product information CAS Number: 82159 09 9 Molecular Weight: 319.

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Description

InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H

As a prodrug

Smiles: COC1=CC2CC[C@H]3[C@@H]4CC[C@H](NCCCCCCN5C(=O)C=CC5=O)[C@@]4(C)CC[C@@H]3C=2C=C1

Smiles: O[C@@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C1=CC(O)=C(O)C(O)=C1

Epalrestat - CAS# 82159-09-9 752 InChi: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9HEpalrestat is an aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. In vivo, Epalrestat treatment significantly ameliorated the bleomycin mediated histological fibrosis alterations and blocked collagen deposition concomitantly with reversing bleomycin induced expression up regulation of TGF 1, AR, SMA and collagen I (both mRNA and protein). Product information CAS Number: 82159 09 9 Molecular Weight: 319.

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