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TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation this gene is established as

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TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation this gene is established asCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only

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Description

this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas

which regulates its nuclear matrix and chromatin association

growth control

Imprinting defects at chromosome 11p13 may contribute to tumorigenesis

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation this gene is established asCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only

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