Perforin 1 Polyclonal Antibody, 50ul ssDNA Synthesis Hydroxysteroid 11-beta dehydrogenase 1 encoded

Hydroxysteroid 11-beta dehydrogenase 1 encoded by HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone

Cell division cycle 27 is a component of the anaphase-promoting complex (APC)

Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia

Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein

Perforin 1 Polyclonal Antibody, 50ul ssDNA Synthesis Hydroxysteroid 11-beta dehydrogenase 1 encodedThe protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T cell and natural killer cell mediated cytolysis. Defects in PRF1 cause familial