PKC Delta Polyclonal Antibody, 50ul[BT-AP07216] Bio-Reaction Tube ABCC12 is a member of

ABCC12 is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein (ATP binding cassette subfamily C member 12) contains two ATP-binding domains and 12 transmembrane regions

Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction

Although several allelic forms of this gene have been identified worldwide

The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system

PKC Delta Polyclonal Antibody, 50ul[BT-AP07216] Bio-Reaction Tube ABCC12 is a member ofProtein kinase C (PKC) is a family of serine and threonine specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile