53BP1 Polyclonal Antibody, 100ul[BT-AP00040] Dry Bath This gene encodes a protein

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity

The encoded protein is present in spermatids

There is a pseudogene of this gene on chromosome 17

It is highly similar to human annexins I and II sequences

53BP1 Polyclonal Antibody, 100ul[BT-AP00040] Dry Bath This gene encodes a proteinThe p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA binding domain of wild type p53, but do not bind mutant p53. The central DNA binding domain of p53 is required for site specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site specific binding also suggests that 53BP1 and 53BP2 are