PAK Alpha/Beta/Gamma Polyclonal Antibody, 100ul[BT-AP06898] Custom RNA Oligos Mutations in this gene cause

Mutations in this gene cause cerebellar ataxia in humans

In metazoa

serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation

|PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins

PAK Alpha/Beta/Gamma Polyclonal Antibody, 100ul[BT-AP06898] Custom RNA Oligos Mutations in this gene causePAK1 encodes a family member of serine threonine p21 activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.