Nibrin Polyclonal Antibody, 50ul[BT-AP06020] Recombinant Protein Expression Following activation

Following activation

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This gene encodes a member of the Rho family of small GTPases

which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB

Nibrin Polyclonal Antibody, 50ul[BT-AP06020] Recombinant Protein Expression Following activationMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.