KLHL13 Monoclonal Antibody, 100ul Aspirating Pipets The protein localizes to nuclear

The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors

The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo

The various isoforms have functional differences| with respect to ARF GAP activity and to G

Mutations in this gene may result in Netherton syndrome

KLHL13 Monoclonal Antibody, 100ul Aspirating Pipets The protein localizes to nuclearThis gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3 based E3 ubiquitin protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.