DCTN4 Polyclonal Antibody, 100ul Immunoassays PML is often involved in

PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL)

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Alternatively spliced transcript variants encoding different isoforms have been identified

Some individuals| as represented by the reference genome allele| contain a 2kb coding region deletion and a start code mutation

DCTN4 Polyclonal Antibody, 100ul Immunoassays PML is often involved inCould have a dual role in dynein targeting and in ACTR1A Arp1 subunit of dynactin pointed end capping. Could be involved in ACTR1A pointed end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.,Belongs to the dynactin subunit 4 family.,subcellular location: Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization