TNR8 Polyclonal Antibody, 20ul Cell Culture Flasks Tumor necrosis factor ligand superfamily

Tumor necrosis factor ligand superfamily member 10 encoded by TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family

Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported

It is one of seven related genes or pseudogenes found in a cluster| thought to result from gene duplication| on chromosome 22

and functions in the p53-dependent DNA damage checkpoint

TNR8 Polyclonal Antibody, 20ul Cell Culture Flasks Tumor necrosis factor ligand superfamilyThe protein encoded by this gene is a member of the TNF receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body